
Deals on vacations and trips to Southeast Missouri
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Southeast Missouri flight + hotel vacation packages
Price found within the past 48 hours. Click for updated prices.

Hilton Garden Inn Chesterfield
per person
Sep 25 - Sep 28
found 20 hours ago
Roundtrip flight included
Denver (DEN) to St. Louis (STL)
This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the 24-hour gym and perks like free self parking.

Moonrise Hotel
Delmar Loop
Save 100% on your flight
per person
Sep 25 - Sep 28
found 20 hours ago
Roundtrip flight included
Denver (DEN) to St. Louis (STL)
The hotel's 24-hour gym, a rooftop terrace, and 2 bars/lounges are among the featured amenities. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public areas, and valet parking. Enjoy a meal from the a restaurant and perks like free self parking.

Crowne Plaza St. Louis Airport by IHG
per person
Sep 25 - Sep 28
found 20 hours ago
Roundtrip flight included
Denver (DEN) to St. Louis (STL)
This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public areas, and free airport shuttle. Enjoy the gym and perks like a free area shuttle.

Ameristar Casino Resort and Spa
Save 100% on your flight
per person
Sep 25 - Sep 28
found 20 hours ago
Roundtrip flight included
Denver (DEN) to St. Louis (STL)
This luxury hotel features a casino, a full-service spa, and 6 restaurants. Enjoy the 2 hot tubs and 24-hour gym, and unwind with a drink at the poolside bar.

Hampton Inn By Hilton St Louis Airport
Woodson Terrace
per person
Sep 25 - Sep 28
found 20 hours ago
Roundtrip flight included
Denver (DEN) to St. Louis (STL)
Self parking is available and the hotel's front desk is staffed around-the-clock. Guests will appreciate freebies like continental breakfast, WiFi in public areas, and a roundtrip airport shuttle. Express check-out is also provided.
Top Southeast Missouri hotels deals

Baymont Inn and Suites by Wyndham Farmington, MO
1625 W Columbia St, Farmington, MO
Free Cancellation
Reserve now, pay when you stay
$56 nightly
The price is $64 total per night
$64 total
Jul 14 - Jul 15
Total includes taxes and fees
This hotel features a 24-hour gym and a seasonal outdoor pool. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will appreciate freebies like buffet breakfast and free self parking.
Pool
Breakfast included

The Riverview
777 Main St, Cape Girardeau, MO
Free Cancellation
Reserve now, pay when you stay
$117 nightly
The price is $132 total per night
$132 total
Jul 9 - Jul 10
Total includes taxes and fees
This hotel features a casino and 2 restaurants. Relax with a drink at one of the 2 bars/lounges and enjoy free perks like free self parking and WiFi in public areas. A coffee shop is provided and the front desk is staffed around-the-clock.
Parking included
Free WiFi

Drury Plaza Hotel Cape Girardeau Conference Center
3351 Percy Drive, Cape Girardeau, MO
Free Cancellation
Reserve now, pay when you stay
$90 nightly
The price is $102 total per night
$102 total
Jul 13 - Jul 14
Total includes taxes and fees
This hotel features an indoor pool, a hot tub, and a restaurant. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the gym and free perks like buffet breakfast and free self parking.
Pool
Hot Tub

Motel 6 Poplar Bluff, MO
4101 Highway 67 N, Poplar Bluff, MO
Free Cancellation
Reserve now, pay when you stay
$79 nightly
The price is $83 total per night
$83 total
Jul 13 - Jul 14
Total includes taxes and fees
This motel doesn't skimp on freebies - guests receive free WiFi and free self parking. Luggage storage is provided and the front desk is staffed around-the-clock.
Pet friendly
Parking included

Best Western Plus Sikeston
120 S Interstate Drive, Sikeston, MO
Free Cancellation
Reserve now, pay when you stay
$89 nightly
The price is $101 total per night
$101 total
Jul 13 - Jul 14
Total includes taxes and fees
This hotel features an indoor pool and a gym. There's no skimping on freebies - guests receive free full breakfast, free WiFi, and free self parking. A 24-hour business center, a grocery/convenience store, and express check-out are also on offer.
Pool
Breakfast included

Tru By Hilton Cape Girardeau
2520 Veterans Memorial Dr, Cape Girardeau, MO
Free Cancellation
Reserve now, pay when you stay
$101 nightly
The price is $115 total per night
$115 total
Jul 14 - Jul 15
Total includes taxes and fees
This hotel features an indoor pool and a gym. Guests will appreciate freebies like daily breakfast and free self parking. Staff at the 24-hour front desk can provide around-the-clock assistance.
Pool
Breakfast included
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View all propertiesLowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Popular places to visit

Elephant Rocks State Park
5/5(13 reviews)
You can take time to visit Elephant Rocks State Park during your travels to Ironton. While you're in the area, wander around the parks.

Echo Bluff State Park
4.5/5(8 reviews)
You can take time to visit Echo Bluff State Park during your travels to Salem. While you're in the area, stroll along the riverfront.

Rocky Falls
4.5/5(2 reviews)
Commune with nature and explore the great outdoors at Rocky Falls during your travels in Winona. While you're in the area, wander around the natural setting.
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