Deals on vacations and trips to Southeast Missouri

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Southeast Missouri flight + hotel vacation packages

Price found within the past 48 hours. Click for updated prices.
The Wildwood Hotel

The Wildwood Hotel

3.5 out of 5
Price was $870, price is now $550 per person
$550
per person
Sep 22 - Sep 26
found 1 day ago
Roundtrip flight included
Los Angeles (LAX) to St. Louis (STL)
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the hot tub and free perks like continental breakfast and free self parking.
Residence Inn by Marriott St Louis Downtown

Residence Inn by Marriott St Louis Downtown

3 out of 5
Midtown
Save 100% on your flight
Price was $968, price is now $601 per person
$601
per person
Sep 22 - Sep 26
found 1 day ago
Roundtrip flight included
Los Angeles (LAX) to St. Louis (STL)
This hotel features an indoor pool and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Self parking, a terrace, and a grocery/convenience store are also offered.
Remodeled and Inviting Free EV

Remodeled and Inviting Free EV

2 out of 5
Save 100% on your flight
Price was $1,080, price is now $680 per person
$680
per person
Sep 22 - Sep 26
found 1 day ago
Roundtrip flight included
Los Angeles (LAX) to St. Louis (STL)
This vacation home doesn't skimp on freebies - guests receive free WiFi and free self parking. A virtual front desk are provided for your convenience.
The Cheshire

The Cheshire

4 out of 5
Price was $860, price is now $626 per person
$626
per person
Sep 22 - Sep 26
found 1 day ago
Roundtrip flight included
Los Angeles (LAX) to St. Louis (STL)
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the seasonal outdoor pool and free English breakfast each morning.
Ameristar Casino Resort and Spa

Ameristar Casino Resort and Spa

4.5 out of 5
Price was $1,022, price is now $790 per person
$790
per person
Sep 22 - Sep 26
found 1 day ago
Roundtrip flight included
Los Angeles (LAX) to St. Louis (STL)
This luxury hotel features a casino, a full-service spa, and 6 restaurants. Enjoy the 2 hot tubs and outdoor pool, and unwind with a drink at the poolside bar.

Top Southeast Missouri hotels deals

Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

3 out of 5
3351 Percy Drive Cape Girardeau MO
Free Cancellation
Reserve now, pay when you stay
The price is $113 total per night
$113 total
per night
Jul 26 - Jul 27
This hotel features an indoor pool, a hot tub, and a restaurant. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the gym and free perks like buffet breakfast and free self parking.
Pool
Hot Tub
Baymont Inn and Suites by Wyndham Farmington, MO

Baymont Inn and Suites by Wyndham Farmington, MO

2.5 out of 5
1625 W Columbia St Farmington MO
Free Cancellation
Reserve now, pay when you stay
The price is $63 total per night
$63 total
per night
Aug 13 - Aug 14
This hotel features a 24-hour gym and a seasonal outdoor pool. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will appreciate freebies like buffet breakfast and free self parking.
Pool
Breakfast included
The Riverview

The Riverview

4 out of 5
777 Main St Cape Girardeau MO
Free Cancellation
Reserve now, pay when you stay
The price is $129 total per night
$129 total
per night
Aug 3 - Aug 4
This hotel features a casino and 2 restaurants. Traveling on business? Take advantage of the free WiFi in public areas, conference center, and conference space. Relax with a drink at one of the 2 bars/lounges and enjoy perks like free self parking.
Parking included
Free WiFi
Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

3 out of 5
2608 East Malone Ave, Miner Sikeston MO
Free Cancellation
Reserve now, pay when you stay
The price is $128 total per night
$128 total
per night
Jul 26 - Jul 27
This hotel features an outdoor pool and an indoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the gym and free perks like buffet breakfast and free self parking.
Pool
Breakfast included
Silo Farm Haus- located in the heart of wine country!

Silo Farm Haus- located in the heart of wine country!

Ste. Genevieve MO
The price is $353 total per night
$353 total
per night
Jul 22 - Jul 23
This country house features laundry facilities.
Laundry
Drury Inn & Suites Hayti Caruthersville

Drury Inn & Suites Hayti Caruthersville

3 out of 5
1317 E Highway 84 Hayti MO
Free Cancellation
Reserve now, pay when you stay
The price is $112 total per night
$112 total
per night
Jul 26 - Jul 27
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the hot tub and free perks like buffet breakfast and free self parking.
Pool
Hot Tub
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Stay near popular Southeast Missouri attractions

A large, reddish-brown rock formation with a smooth, rounded surface and a unique, intertwined shape.
Photo by Pat Long
Open Photo by Pat Long

Elephant Rocks State Park

9.6/10 (98 reviews)
You can take time to visit Elephant Rocks State Park during your travels to Ironton. While you're in the area, wander around the parks.
See properties

Frequently asked questions

How much are vacation packages to Southeast Missouri?
Packages, which include flights and hotels in Southeast Missouri, start at just $550. Make your travel dreams a reality and book your dream trip with Travelocity today.
Where can I get the best vacation package deals for Southeast Missouri?
There are fantastic Southeast Missouri package deals to score with Travelocity. Did you know we partner with as many as 400 airlines and 1,000,000 properties around the globe? Keep that in mind when you're ready to cross another place off your travel bucket list.
Why should I book my Southeast Missouri vacation package via Travelocity?
From incredible destinations to thrilling experiences, we have everything you need to satisfy your love for travel. Our 24/7 customer care will also ensure you're being taken care of before, during and after your trip. And don't panic if you notice a lower price on your booking, we'll match it. That's our Price Match Guarantee.
Will I save money on my Southeast Missouri car rental if I bundle it with my hotel or flight?
Absolutely. And our Southeast Missouri vacation packages are the perfect way to do it. With just a few clicks you can save cash as well as time by combining your bookings. Collect the keys to your rental car then set your own course. Looking for things to do? Add some tours or experiences to your package and make savings on those too.
Which airport is best for Southeast Missouri?
Cape Girardeau Municipal Airport (CGI) is the main airport that has flights in and out of Southeast Missouri.
What is there to do in Southeast Missouri?
Southeast Missouri has hidden gems around every corner, but make sure you visit Johnson's Shut-ins State Park and Meramec Caverns while you're here. These landmarks shouldn't be missed.

Photos of local treasures

Browse Southeast Missouri vacation photos for more inspiration

A group of men in red uniforms with gold accents, holding rifles and wearing kilts.
A river flowing through a rocky landscape with dense green forest in the background.
A rocky river with clear water flowing over rocks.
A rocky shoreline with a calm lake and distant islands.
A river running through a forested landscape with a dirt road parallel to the river.

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