Southeast Missouri Vacation Packages 2026 from $454

Southeast Missouri flight + hotel vacation packages

Price found within the past 48 hours. Click for updated prices.

Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West

Riverport

$454

per person

Nov 5 - Nov 8

found 1 day ago

Roundtrip flight included

Miami (MIA) to St. Louis (STL)

This hotel features an indoor pool and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will appreciate freebies like continental breakfast and free self parking.

Moonrise Hotel

Delmar Loop

$543

per person

Nov 5 - Nov 8

found 1 day ago

Roundtrip flight included

Miami (MIA) to St. Louis (STL)

The hotel's 24-hour gym, a rooftop terrace, and 2 bars/lounges are among the featured amenities. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy a meal from the a restaurant and perks like free self parking.

Gray Plaza Motel Benton Rend Lake I-57

$703

per person

Oct 21 - Oct 26

found 4 hours ago

Roundtrip non-stop flight included

Orlando (MCO) to Veterans Airport of Southern Illinois (MWA)

Free self parking is available and the motel's front desk is staffed around-the-clock. Guests will appreciate free perks like continental breakfast and WiFi in public areas. A fireplace in the lobby is also provided.

Country Inn & Suites by Radisson, Marion, IL

$834

per person

Oct 21 - Oct 26

found 4 hours ago

Roundtrip non-stop flight included

Orlando (MCO) to Veterans Airport of Southern Illinois (MWA)

This hotel doesn't skimp on freebies - guests receive free continental breakfast, free WiFi, and free self parking. Traveling on business? Take advantage of the 24-hour business center and free internet in public areas. There's a gym on site, and a 24-hour front desk and a fireplace in the lobby are also provided.

Top Southeast Missouri hotels deals

Drury Plaza Hotel Cape Girardeau Conference Center

3351 Percy Drive Cape Girardeau MO

Free Cancellation

Reserve now, pay when you stay

$100 nightly

$113 total

Sep 17 - Sep 18

Total with taxes and fees

This hotel features an indoor pool, a hot tub, and a restaurant. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the gym and free perks like buffet breakfast and free self parking.

Comfort Inn Festus - St Louis South

1303 Veterans Blvd Festus MO

Free Cancellation

$73 nightly

$83 total

Oct 11 - Oct 12

Total with taxes and fees

This hotel doesn't skimp on freebies - guests receive free buffet breakfast, free WiFi, and free self parking. Business travelers can take advantage of the business center. Enjoy the gym and conveniences like a 24-hour front desk and laundry facilities.

Baymont Inn and Suites by Wyndham Farmington, MO

1625 W Columbia St Farmington MO

Free Cancellation

Reserve now, pay when you stay

$57 nightly

$62 total

Sep 20 - Sep 21

Total with taxes and fees

This hotel features a 24-hour gym and a seasonal outdoor pool. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will appreciate freebies like buffet breakfast and free self parking.

Pear Tree Inn Cape Girardeau West

103 Cape West Pkwy Cape Girardeau MO

Free Cancellation

Reserve now, pay when you stay

$72 nightly

$81 total

Sep 20 - Sep 21

Total with taxes and fees

This hotel doesn't skimp on freebies - guests receive free buffet breakfast, free WiFi, and free self parking. Business travelers can take advantage of the 24-hour business center. A safe deposit box is provided and the front desk is staffed around-the-clock.

The Riverview

777 Main St Cape Girardeau MO

Free Cancellation

Reserve now, pay when you stay

$104 nightly

$117 total

Oct 12 - Oct 13

Total with taxes and fees

This hotel features a casino and 2 restaurants. Traveling on business? Take advantage of the free WiFi in public areas, conference center, and conference space. Relax with a drink at one of the 2 bars/lounges and enjoy perks like free self parking.

Silo Farm Haus- located in the heart of wine country!

Ste. Genevieve MO

$331 nightly

$370 total

Sep 13 - Sep 14

Total with taxes and fees

This vacation home features laundry facilities.

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Stay near popular Southeast Missouri attractions

A large, reddish-brown rock formation with a smooth, rounded surface and a unique, intertwined shape.

Elephant Rocks State Park

9.6/10 (98 reviews)

You can take time to visit Elephant Rocks State Park during your travels to Ironton. While you're in the area, wander around the parks.

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Frequently asked questions

How much are vacation packages to Southeast Missouri?

Packages, which include flights and hotels in Southeast Missouri, start at just $454. Make your travel dreams a reality and book your dream trip with Travelocity today.

Where can I get the best vacation package deals for Southeast Missouri?

There are fantastic Southeast Missouri package deals to score with Travelocity. Did you know we partner with as many as 400 airlines and 1,000,000 properties around the globe? Keep that in mind when you're ready to cross another place off your travel bucket list.

Why should I book my Southeast Missouri vacation package via Travelocity?

From incredible destinations to thrilling experiences, we have everything you need to satisfy your love for travel. Our 24/7 customer care will also ensure you're being taken care of before, during and after your trip. And don't panic if you notice a lower price on your booking, we'll match it. That's our Price Match Guarantee.

Will I save money on my Southeast Missouri car rental if I bundle it with my hotel or flight?

Absolutely. And our Southeast Missouri vacation packages are the perfect way to do it. With just a few clicks you can save cash as well as time by combining your bookings. Collect the keys to your rental car then set your own course. Looking for things to do? Add some tours or experiences to your package and make savings on those too.

Which airport is best for Southeast Missouri?

Cape Girardeau Municipal Airport (CGI) is the main airport that has flights in and out of Southeast Missouri.

What is there to do in Southeast Missouri?

Southeast Missouri has hidden gems around every corner, but make sure you visit Johnson's Shut-ins State Park and Meramec Caverns while you're here. These landmarks shouldn't be missed.